Altered Sleep Homeostasis in Knockout Mice

Two Distinctive Biological Timing Processes Interact in the Creation of a Rest-activity Cycle - the Circadian Oscillator and the Sleep

695 PER3 Promoter, Diurnal Preference and DSPD—Archer et al TWO DISTINCTIVE BIOLOGICAL TIMING PROCESSES INTERACT IN THE CREATION OF A REST-ACTIVITY CYCLE THE CIRCADIAN OSCILLATOR AND THE SLEEP homeostat.1 In mammals, the circadian oscillation is driven by a negative feedback loop involving the Period (Per1, Per2, and Per3) and Cryptochrome (Cry1 and Cry2) genes, whose transcription is initiated...

Spontaneous , homeostatic , and inflammation - induced sleep in NF - κ B p 50 knockout mice

Spontaneous, homeostatic, and inflammation-induced sleep in NF-kappaB p50 knockout mice.

The dimeric transcription factor nuclear factor-kappaB (NF-kappaB) regulates several endogenous sleep-modulatory substances and thereby serves as a pivotal mediator of sleep-wake homeostasis. To further define the role of NF-kappaB in sleep regulation, we monitored sleep and temperature in mice that lack the p50 subunit of NF-kappaB [p50 knockout (KO) mice]. Compared with the control B6129PF2/J...

Sleeping Beauty, Mice, & Dogs: Cell Death in Narcolepsy

Sleep is important and required for the survival and normal homeostasis of vertebrates. Disturbances in the sleep-wake cycle can lead to many sleep disorders, one of which is narcolepsy. Narcolepsy is a disabling sleep disorder characterized by excessive daytime sleep, cataplexy (sudden loss of muscle tone in response to strong emotion or laughter), hallucinations, and sleep paralysis. To date,...

The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study.

Nuclear factor E2-related factor 2 (NRF2) and uncoupling protein 2 (UCP2) are indicated to protect from oxidative stress. They also play roles in the homeostasis of glutathione. However, the detailed mechanisms are not well understood. In the present study, we found Nrf2-knockout (Nrf2-KO) mice exhibited altered glutathione homeostasis and reduced expression of various genes involved in GSH bio...